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(1) Zhu, J.,Wang, Y. F.,Song, S. S.,Wu, L. L.,Chen, Y.,Li, X. Y.,& Ju, M. (2023). Alleviating skin barrier disruption, skin inflammation, and Pruritus: a moisturising spray containing β-glucan and panthenol. International Journal of Dermatology and Venereology, 6(01), 1-8.
(2) Proksch E, de Bony R, Trapp S, et al. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat 2017;28(8):766-773.
(3) Scott LN, Fiume M, Bergfeld WF, et al. Safety assessment of panthenol, pantothenic acid, and derivatives as used in cosmetics. International Journal of Toxicology. 2022;41(3_suppl):77-128. doi:10.1177/10915818221124809
(4) Camargo Jr, F. B.,Gaspar, L. R.,& Maia Campos, P. M. (2011). Skin moisturizing effect of panthenol-based formulations. Journal of cosmetic science, 62(4), 361.
5 Gorski, J.,Proksch, E.,Baron, J. M.,Schmid, D.,& Zhang, L. (2020). Dexpanthenol in wound healing after medical and cosmetic interventions (post procedure wound healing). Pharmaceuticals, 13(7), 138.
6Baron, J. M.,Glatz, M.,& Proksch, E. (2020). Optimum support for wound healing: new Insights. Dermatology, 236(6), 593-600.
PANTHENOL
Panthenol, also known as pro-vitamin B5, is well absorbed when applied topically to the skin and is rapidly oxidized enzymatically in the body to pantothenic acid (vitamin B5). Vitamin B5 is a component of coenzyme A, which is involved in various physiological processes such as intracellular lipid synthesis in the epidermis.(1)(2) Panthenol penetrates the skin better than Vitamin B5 and is very well tolerated.(1-3) Panthenol has a skin-caring and moisturizing effect and strengthens the skin's barrier function. (2-5) For individuals with dry skin, it addresses the lower hydration levels by boosting the water content and favorably impacting the molecular movement of the lipid layers and proteins in the stratum corneum, which in turn helps to reduce transepidermal water loss. (4)(5) Panthenol can support wound healing in burns, scalds, corneal lesions, and allergic dermatitis in all three phases of wound healing and has a protective effect against skin irritations. (5)(6)
(1) Zhu, J.,Wang, Y. F.,Song, S. S.,Wu, L. L.,Chen, Y.,Li, X. Y.,& Ju, M. (2023). Alleviating skin barrier disruption, skin inflammation, and Pruritus: a moisturising spray containing β-glucan and panthenol. International Journal of Dermatology and Venereology, 6(01), 1-8.
(2) Proksch E, de Bony R, Trapp S, et al. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat 2017;28(8):766-773.
(3) Scott LN, Fiume M, Bergfeld WF, et al. Safety assessment of panthenol, pantothenic acid, and derivatives as used in cosmetics. International Journal of Toxicology. 2022;41(3_suppl):77-128. doi:10.1177/10915818221124809
(4) Camargo Jr, F. B.,Gaspar, L. R.,& Maia Campos, P. M. (2011). Skin moisturizing effect of panthenol-based formulations. Journal of cosmetic science, 62(4), 361.
5 Gorski, J.,Proksch, E.,Baron, J. M.,Schmid, D.,& Zhang, L. (2020). Dexpanthenol in wound healing after medical and cosmetic interventions (post procedure wound healing). Pharmaceuticals, 13(7), 138.
6Baron, J. M.,Glatz, M.,& Proksch, E. (2020). Optimum support for wound healing: new Insights. Dermatology, 236(6), 593-600.
