BIFIDA FERMENT LYSATE

Bifida Ferment Lysate is a postbiotic and is obtained from the fermentation of the bacterial species Bifidobacterium longum. We use the Repair Complex of CLR, in this lysate the bacteria are inactivated, but the valuable metabolic products, cytoplasmic fractions, cell wall components, and polysaccharide complexes are still present.

The function of this ferment includes the improvement of visible skin redness and skin irritations, as well as the reduction of inflammatory reactions in the skin by decreasing the release of inflammatory mediators. (1)

Additionally, experiments show that Bifida Ferment Lysate can statistically significantly improve the expression of numerous barrier genes and antimicrobial peptides in human keratinocytes (skin cells). (2) (3) Through this strengthening of the skin barrier's resilience, this ferment demonstrated in studies the ability to protect the skin from oxidative stress and inflammatory stimuli. (3)

The skin barrier is crucial for protecting the body from harmful environmental influences. Loricrin is an important protein that is cross-linked during the keratinization of the skin, and it plays a crucial role in the skin barrier function. Bifida Ferment Lysate led to an increase in the expression of loricrin as well as other molecules (filaggrin, involucrin, transglutaminase 1) in human skin cells, all of which are significant for the skin barrier function. (3)

Another important factor for healthy skin is the moisture content. Aquaporin 3 is the most important channel protein in the skin that regulates water content. It has been shown that Bifida Ferment Lysate increases Aquaporin 3, leading to an improvement in the moisture content of the skin. (3)

Furthermore, antimicrobial peptides play an important role in defending against pathogens. These peptides can combat pathogens directly through their antibacterial action or indirectly via inflammatory pathways. Bifida Ferment Lysate has been associated with an increased expression of antimicrobial peptides, such as CAMP and hBD-2, suggesting that it may strengthen the skin's first line of defense against pathogens. (3)

Environmental factors such as UV radiation, visible light, and pollution increase the production of reactive oxygen species (ROS) in the skin and can cause oxidative stress. Oxidative stress can disrupt the skin barrier and enhance inflammatory reactions. A recent study showed that Bifida Ferment Lysate is capable of efficiently capturing free radicals and increasing antioxidant enzyme activities, which helps to reduce oxidative stress in skin cells. (3)

(1) Guéniche, A., Bastien, P., Ovigne, J. M., Kermici, M., Courchay, G., Chevalier, V., Breton, L., & Castiel-Higounenc, I. (2010). Bifidobacterium longum lysate, a new ingredient for reactive skin. Experimental dermatology, 19(8), e1–e8. https://doi.org/10.1111/j.1600-0625.2009.00932.

(2) Szöllősi, A. G., Gueniche, A., Jammayrac, O., Szabó-Papp, J., Blanchard, C., Vasas, N., Andrási, M., Juhász, I., Breton, L., & Bíró, T. (2017). Bifidobacterium longum extract exerts pro-differentiating effects on human epidermal keratinocytes, in vitro. Experimental dermatology, 26(1), 92–94. https://doi.org/10.1111/exd.13130

(3) Wang, R., Yan, S., Ma, X., Zhao, J., Han, Y., Pan, Y., & Zhao, H. (2023). The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defence in vitro. Journal of cosmetic dermatology, 10.1111/jocd.15831. Advance online publication. https://doi.org/10.1111/jocd.15831