3-O-ETHYL ASCORBIC ACID

The chemical compound 3-Ethyl-Ascorbic Acid is a stable vitamin C derivative and is used in cosmetics for its brightening, antioxidant, anti-inflammatory, and elasticity-enhancing properties. (1,2,3) In a study, an improved epidermal-dermal microstructure and a reduction of fine lines and wrinkles were achieved after application using an emulsion (O/W) with 3% ascorbic acid. (4)

(1) Iliopoulos F, Sil BC, Moore DJ, Lucas RA, Lane ME (2019). 3-O-ethyl-l-ascorbic acid: Characterization and investigation of single solvent systems for delivery to the skin. Int J Pharm X.

(2) Liao WC, Huang YT, Lu LP, Huang WY (2018). Antioxidant Ability and stability studies of 3-O-ethyl ascorbic acid, a cosmetic tyrosinase inhibitor. J Cosmet Sci, 69(4), 233-243.

(3) Golonka, I., Oleksy, M., Junka, A., Matera-Witkiewicz, A., Bartoszewicz, M., & Musiał, W. (2017). Selected physicochemical and biological properties of ethyl ascorbic acid in comparison to ascorbic acid. Biological & pharmaceutical bulletin, 40(8), 1199–1206.

(4) T. Raschke, U. Koop, H.-J. Düsing, A. Filbry, K. Sauermann, S. Jaspers, H. Wenck, K.-P. Wittern (2004). Topical Activity of Ascorbic Acid: From in vitro Optimization to in vivo Efficacy.  Skin Pharmacology and Applied Skin Physiology, 17 (4), 200–206.