PALMITOYL PENTAPEPTIDE-4

Palmitoyl-Pentapeptide-4 is a peptide obtained as a reaction product of palmitic acid and pentapeptide-4. It is also called Matrixyl and consists of a short peptide chain with five amino acids (lysine, threonine, threonine, lysine, serine) bound to palmitic acid.

Palmitoyl-pentapeptide-4 is a biologically active peptide that is reported to stimulate the production of elastin, fibronectin, glycosaminoglycan, and collagens (particularly types I, III, and IV) as well as aid in wound healing.1Studies have shown it to be effective in reducing periorbital wrinkles by decreasing wrinkle depth and increasing skin barrier function and skin elasticity. (1) (2) (3)

(1) Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Kosmetik, 4(2), 16.

(2) Suhendra, N. N. (2020, August). The efficacy of 7% palmitoyl pentapeptide-4 serum for the periorbital wrinkle reduction. In Rangsit Graduate Research Conference: RGRC (Vol. 15, No. 2563), pp. 2870-2884).

(3) Aruan, R. R.,Hutabarat, H.,Widodo, A. A.,Firdiyono, M. T. C. C.,Wirawanty, C.,& Fransiska, L. (2023). Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet. The Journal of Clinical and Aesthetic Dermatology, 16(2), 37–43.